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Abnormality of Circadian Rhythm of Serum Melatonin and Other Biochemical Parameters in Fibromyalgia Syndrome

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Title Abnormality of Circadian Rhythm of Serum Melatonin and Other Biochemical Parameters in Fibromyalgia Syndrome
 
Creator Mahdi, Abbas Ali
Fatima, Ghizal
Das, Siddhartha Kumar
Verma, Nar Singh
 
Subject Fibromyalgia syndrome
Circadian rhythm, Melatonin
Cortisol
Serotonin
IL-6
TNF-alpha
 
Description 82-87
Fibromyalgia syndrome (FMS) is a complex chronic
condition causing widespread pain and variety of other symptoms. It produces
pain in the soft tissues located around joints throughout the body. FMS has
unknown etiology and its pathophysiology is not fully understood. However,
abnormality in circadian rhythm of hormonal profiles and cytokines has been
observed in this disorder. Moreover, there are reports of deficiency of
serotonin, melatonin, cortisol and cytokines in FMS patients, which are fully
regulated by circadian rhythm. Melatonin, the
primary hormone of the pineal gland regulates the body’s circadian rhythm and
normally its levels begin to rise in the mid-to-late evening, remain high for
most of the night, and then decrease in the early morning. FMS patients
have lower melatonin secretion during the hours of darkness than the healthy
subjects. This may contribute to impaired sleep at night, fatigue during the
day and changed pain perception. Studies have shown blunting of normal diurnal
cortisol rhythm, with elevated evening serum cortisol level in patients with
FMS. Thus, due to
perturbed level of cortisol secretion several symptoms of FMS may occur. Moreover,
disturbed cytokine levels have also been reported in FMS patients. Therefore, circadian rhythm can be an important
factor in the pathophysiology, diagnosis and treatment of FMS. This article
explores the circadian pattern of abnormalities in FMS patients, as this may
help in better understanding the role of variation in
symptoms of FMS and its possible relationship with circadian variations of
melatonin, cortisol, cytokines and serotonin levels.
 
Date 2011-04-26T06:51:58Z
2011-04-26T06:51:58Z
2011-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/11609
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(2) [April 2011]