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<img src='/image/spc_char/alpha.gif' border=0> -Tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode <i>Caenorhabdtis elegans</i>

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Title -Tocopherol ameliorates cypermethrin-induced toxicity and oxidative stress in the nematode Caenorhabdtis elegans
 
Creator Shashikumar, Shivaiah
Rajini, P S
 
Subject Cypermethrin
Caenorhabditis elegans
Oxidative stress
-Tocopherol
 
Description 191-196
Oxidative stress and
other effects induced by cypermethrin (CYP, 15 mM) and their amelioration by -tocopherol
(400 M) was studied in the nematode Caenorhabditis
elegans. The worms exposed for 4 h to CYP showed increased  levels of reactive oxygen species (46%), H2O2
(37%) and protein carbonyls (29%), accompanied by decreased lifespan and
brood size. However,  exposure to both
CYP and a-tocopherol resulted in diminution of
above alterations with the worms exhibiting relatively lower levels of ROS
(30%), H2O2 (15%), protein carbonyls (14%), altered
antioxidant enzyme activities and normal lifespan and brood size. The results
suggest that CYP induces oxidative stress in C. elegans and the strategy
of intervention with -tocopherol
could be exploited to offset this induced oxidative stress.
 
Date 2011-06-16T09:14:46Z
2011-06-16T09:14:46Z
2011-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/11988
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(3) [June 2011]