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Neuroprotective potential of ethanolic extract of<i style=""> Pseudarthria viscida </i>(L) Wight and Arn<i style=""> </i>against <img src='/image/spc_char/beta.gif' border=0>-amyloid<sub>(25-35)</sub>-induced amnesia in mice

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Title Neuroprotective potential of ethanolic extract of Pseudarthria viscida (L) Wight and Arn against -amyloid(25-35)-induced amnesia in mice
 
Creator Singh, J C Hanish
Alagarsamy, V
Parthiban, P
Selvakumar, P
Reddy, Y Narsimha
 
Subject Alzheimer’s disease
-Amyloid
Acetylcho-linesterase
Water maze
Oxidative stress
Pseudarthria viscida (L) Wight and Arn
Antioxidant enzymes
Vitamin C
 
Description 197-201
The neuroprotective potential of
ethanolic extract of roots of Pseudarthria
viscida (L) Wight and Arn (EEPV) was investigated against -amyloid(25-35)-induced
amnesia in mice which is a suitable animal model for Alzheimer’s disease (AD). The
senile plaques of
-amyloid (A) are major constituents accumulated during the progression of AD as
a potent neurotoxicant. In our investigation, intracerebroventricular injection
of A(25-35) in mice induced the neurodegeneration, exhibited the
increased time of escape latency in behavioral pattern using water maze and
decreased the levels of antioxidants namley superoxide dismutase (SOD),
glutathione peroxidase (GPx), catalase (CAT) and vitamin C with elevated level
of acetylcholinesterase enzyme (AChE). The neuroprotective potential of EEPV was
determined by behavioral pattern using water maze and biochemical parameters
such as SOD, CAT and GPx and vitamin C content as well as AChE. Mice were
treated with EEPV at 200 and 400 mg/kg doses for 21 days. Except control, all
animals received a single injection of neurotoxicant A(25-35) on 14th
day. In behavioural assessment, treatment with ethanolic extract improved the
cognitive function in the water maze and attenuated the elevated levels of AChE
with increase in antioxidant enzymes, indicating the neuroprotection with
increased levels of vitamin C. These findings suggest that ethanolic extract of
P. viscida exerts anti-amnesiac
effects and enhances cognitive function.
 
Date 2011-06-16T09:15:46Z
2011-06-16T09:15:46Z
2011-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/11989
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(3) [June 2011]