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Early Growth Response 1— A Transcription Factor in the crossfire of Signal Transduction Cascades

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Title Early Growth Response 1— A Transcription Factor in the crossfire of Signal Transduction Cascades
 
Creator Pagel, Judith-Irina
Deindl, Elisabeth
 
Subject Egr-1
MEK/ERK
Serum response factor
Transcription factor
Rho-kinase
Signal transduction cascades
 
Description 226-235
Early growth response-1 (Egr-1) is a
Cys2-His2-type zinc-finger transcription factor. A broad range of extracellular
stimuli is capable of activating Egr-1, thus mediating growth, proliferation,
differentiation or apoptosis. Egr-1 is, therefore, participating in the
progression of a variety of diseases such as atherosclerosis or cancer.
Functional response elements connect Egr-1 to signal transduction cascades
targeting Egr-1. Five serum response elements (SRE) have been identified in the
promoter region of Egr-1, the binding region of serum response factor (SRF).
The Rho/Rho-kinase pathway has been shown to regulate actin reorganization via
LIM-kinase mediated cofilin phosphorylation. Recent studies have revealed that
the actin binding striated muscle activator of Rho signaling (STARS) promotes translocation
of myosin related transcription factors (MRTFs) into the nucleus, leading to
SRF activation. The ternary complex factor (TCF) Elk-1 eventually bridges the
gap between SRF-mediated gene transcription and the Raf/MEK/ERK pathway.
Moreover, the Egr-1 promoter owns two cAMP response elements (CREs), whose
relevance for gene expression is still unclear. An Egr-1 binding site (EBS)
located on the Egr-1 promoter itself is arguing for a negative feedback
mechanism. The acquired knowledge on transcriptional regulation of Egr-1 is not
entirely understood. In this review, we highlight upstream and downstream
signaling in vitro and in vivo associated with Egr-1.
 
Date 2011-09-16T04:37:34Z
2011-09-16T04:37:34Z
2011-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/12697
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(4) [August 2011]