Record Details

HSP70 Expression and its Role in Preeclamptic Stress

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title HSP70 Expression and its Role in Preeclamptic Stress
 
Creator Ekambaram, Padmini
 
Subject Preeclampsia
HSP70
Stress
Mint-tea
Ureaplasma urealyticum
 
Description 243-255
Preeclampsia,
a hypertensive pregnancy-specific disorder, has long been analyzed for its
association with cellular stress. It still remains one of the most serious
complications of pregnancy. It is a multi-system disorder that affects maternal
vascular function and fetal growth. The physiopathology of preeclampsia is
still unclear, but an imbalance between reactive oxygen species (ROS) and
antioxidants, appears to be an important contributing factor. Oxidative stress
has been increasingly postulated as a major contributor to endothelial
dysfunction in preeclampsia (PE). The ROS promotes lipid oxidation and are
known to induce stress proteins, such as hemeoxygenase 1 (HO-1) and heat-shock
protein 70 (HSP70). Embryonic and placental cells are highly sensitive to oxidative
stress due to their proliferate nature. Endothelial cell dysfunction is
suggested to be a part of wider maternal inflammatory reaction responsible for
the clinical syndrome of preeclampsia. Part of the dysfunction in endothelial
cell and trophoblast is attributed to oxidative stress developed during
pregnancy. The disequilibrium in compensatory antioxidant control is proposed
as a causative mechanism in the pathophysiology of preeclampsia. HSP70 acts as
the secondary line of defense in systems with compromised antioxidant function.
This article reviews the differential expression of HSP70 and the effect of
mint-tea therapy to modulate preeclamptic oxidative damage.
 
Date 2011-09-16T04:38:04Z
2011-09-16T04:38:04Z
2011-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/12699
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(4) [August 2011]