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Modulatory effect of plasma folate and polymorphisms in one-carbon metabolism on catecholamine methyltransferase (COMT) H108L associated oxidative DNA damage and breast cancer risk

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Title Modulatory effect of plasma folate and polymorphisms in one-carbon metabolism on catecholamine methyltransferase (COMT) H108L associated oxidative DNA damage and breast cancer risk
 
Creator Naushad, Shaik Mohammad
Pavani, Addepalli
Rupasree, Yedluri
Sripurna, Deepti
Gottumukkala, Suryanarayana Raju
Digumarti, Raghunadha Rao
Kutala, Vijay Kumar
 
Subject Catechol-O-methyltransferase (COMT)
8-Oxo-2’-deoxyguanosine (8-oxodG)
One-carbon metabolism
Oxidative DNA damage
Breast cancer
Polymorphism
Plasma folate
 
Description 283-289
The present study was aimed to investigate
the modulatory role of plasma folate and eight putatively functional
polymorphisms of one-carbon metabolism on catecholamine methyltransferase
(COMT)-mediated oxidative DNA damage and breast cancer risk. Plasma folate and
8-oxo-2’-deoxyguanosine (8-oxodG) were estimated by commercially available
kits, while polymorphisms were screened by PCR-RFLP and PCR-AFLP methods. COMT
H108L polymorphism showed independent association with breast cancer (OR: 1.73,
95% CI: 1.31-2.30). No significant interaction was observed between folate
status and COMT genotype. Multifactor dimensionality reduction (MDR) analysis
gave evidence for the significant epistatic (gene-gene) interactions (p
 
Date 2011-09-16T04:39:41Z
2011-09-16T04:39:41Z
2011-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/12704
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.48(4) [August 2011]