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Antihyperglycemic and antioxidant effect of hydroethanolic extract of <i style="">Butea monosperma</i> bark in diabetic mice

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Title Antihyperglycemic and antioxidant effect of hydroethanolic extract of Butea monosperma bark in diabetic mice
 
Creator Sharma, Nidhi
Garg, Veena
 
Subject Antidiabetic
Antioxidant
Butea Monosperma
Diabetes Mellitus
Oxidative Stress
 
Description 55-62
The antihyperglycemic, antihyperlipidemic and antioxidative properties of
hydroethanolic extract of Butea
monosperma bark were investigated in alloxan-induced diabetic mice. Alloxan
administration resulted in higher blood glucose level and reduced hepatic
glycogen content as compared to normal animals. Besides, serum lipid profile
parameters such as total cholesterol (TC), triglyceride (TG), low density
lipoprotein (LDL) and very low density lipoprotein (VLDL) cholesterol were also
found to be significantly elevated, whereas the level of high density
lipoprotein (HDL) cholesterol was markedly reduced in diabetic animals. Oxidative damage in the tissues of diabetic mice was
evidenced by a marked increase in the level of thiobarbituric acid reactive
substances (TBARS), distinct decrease in reduced glutathione (GSH) content and
declined activity of antioxidant enzymes, such as superoxide dismutase (SOD),
catalase (CAT) and glutathione peroxidase (GSH-Px). The daily treatment of
diabetic animals with crude extract of B.
monosperma bark (300 mg kg-1) for 45 days significantly lowered
blood glucose level and elevated hepatic glycogen content, bringing the values
close to those observed in normal control and glibenclamide-treated diabetic
mice. Furthermore, the level of various lipid profile parameters was also
reversed towards normal. TBARS and GSH also restored towards
normal and the declined activity of antioxidant enzymes in diabetic animals was
also normalized in crude extract administered mice, thus indicating the
antioxidant efficacy of the drug in diabetes-induced oxidative damage. Significant
antihyperglycemic and antioxidant potential of the crude extract of B. monosperma bark indicated that it may
find use in the management of diabetes and resultant oxidative stress
 
Date 2012-02-14T12:28:42Z
2012-02-14T12:28:42Z
2012-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/13592
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(1) [February 2012]