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Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients

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Title Relation of CuZnSOD activity with renal insufficiency in hypertensive diabetic patients
 
Creator Stancic, Ana
Rasic-Milutinovic, Zorica
Perunicic-Pekovic, Gordana
Buzadzic, Biljana
Korac, Aleksandra
Otasevic, Vesna
Jankovic, Aleksandra
Vucetic, Milica
Korac, Bato
 
Subject Diabetes
Renal Insufficiency
CuZnSOD Activity
 
Description 97-100
Diabetes and
renal insufficiency are interrelated metabolic disorders closely associated
with redox homeostasis disturbances. The aim of this study was to compare the
activity of copper zinc superoxide dismutase (CuZnSOD) in the erythrocytes of
hypertensive diabetic patients with or without renal insufficiency with normal
healthy control subjects. In both groups of diabetic patients, blood glucose
level and the content of glycosylated hemoglobin (HbA1c) were higher
than in the control group. However, CuZnSOD activity was significantly higher
than control only in hypertensive diabetic patients with renal insufficiency.
Our results suggest that disturbances in superoxide homeostasis do correlate
with long-term complication in diabetes, i.e. diabetic renal insufficiency and
hypertension.
 
Date 2012-04-17T08:54:03Z
2012-04-17T08:54:03Z
2012-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/13840
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(2) [April 2012]