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6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration

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Title 6 Paths of ERK5 signaling pathway regulate hepatocyte proliferation in rat liver regeneration
 
Creator Li, Zhanpeng
Cheng, Zhenchao
Wang, Gaiping
Hao, Xioxia
Zhang, Lijun
Xu, Cunshuan
 
Subject ERK5 signaling pathway
Rat liver regeneration
Hepatocyte proliferation
Rat genome 230 2.0 array
Gene expression profiles
 
Description 165-172
Generally, extra-cellular-signal-regulated
kinase 5 (ERK5) signaling pathway regulates many physiological activities, such
as cell proliferation and cell differentiation. However, little is known about
how ERK5 signaling pathway composed of 15 paths participates in regulating
hepatocyte proliferation during liver regeneration (LR). In this study, to explore
the influence ERK5 signaling pathway upon hepatocytes at gene transcription
level, rat genome 230 2.0 array was used to detect expression changes of 75
related genes in isolated hepatocytes from rat regenerating liver.
Bioinformatics and systems biology methods were applied to analyze the precise
role of ERK5 signaling pathway in regulating hepatocyte proliferation during
LR. Results showed that 62 genes were contained in the array and 22 genes were
significantly changed. It was found that 6 paths were related to hepatocyte
proliferation during rat LR. Among them, paths 3, 6 and 13 of ERK5 signaling
pathway modulated cell cycle progression by decreasing the negative influence
on ERK5 and paths 3, 4, 8 and 9 by reinforcing the positive influence on ERK5. In
summary, the study shows that 22 genes and 6 paths of ERK5
signaling pathway participate in regulating proliferation of hepatocytes in rat
LR.
 
Date 2012-06-18T11:31:50Z
2012-06-18T11:31:50Z
2012-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/14276
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(3) [June 2012]