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Role of PPARβ in fibroblast response to heat injury

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Title Role of PPARβ in fibroblast response to heat injury
 
Creator Zuo, Chenchen
Liang, Pengfei
Huang, Xiaoyuan
 
Subject PPARβ
Fibroblast
Heat injury
In vitro wound healing model
 
Description 219-227
Peroxisome
proliferator-activated receptors (PPARs) belong to the nuclear hormone receptor
family of ligand-inducible transcription factors. Our previous study has shown that in human umbilical vein
endothelial cells
PPARβ initiates a protective mechanism that limits the
extent of damage due to H2O2-induced injury. Although fibroblasts are
one of the main cell types involved in wound repair, the
role of PPARβ in the fibroblast response
to heat injury has not been investigated. Thus, in this
study, we examined possible protective role of PPARβ in fibroblasts from heat injury. We developed a novel dermal fibroblast heat
injury model to characterize the mechanisms of the heat injury healing response
that involved PPARβ. The specific PPARβ ligand GW0742, a PPARβ activator and a short hairpin
RNA (shRNA) plasmid against PPARβ were used to reveal the
action mechanism of PPARβ in heat injury-induced fibroblast changes in
morphology and increased proliferation. In response to heat
injury (
 
Date 2012-08-07T11:18:31Z
2012-08-07T11:18:31Z
2012-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/14537
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(4) [August 2012]