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<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Bioactive hyaluronan fragment (hexasaccharide) detects specific hexa-binding proteins in human breast and stomach cancer: Possible role in tumorogenesis</span>

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Title Bioactive hyaluronan fragment (hexasaccharide) detects specific hexa-binding proteins in human breast and stomach cancer: Possible role in tumorogenesis
 
Creator Srinivas, Prashanth
Kollapalli, Srinivas Prasad
Thomas, Anil
 
Subject Hyaluronan
CD44
Breast cancer
Stomach cancer
Fibroadenoma
Tumorogenesis
 
Description 228-235
Hyaluronan (HA) is a component of extracellular
matrix that influences cell-proliferation, migration, development,
regeneration, normal tissue remodeling, tissues undergoing malignancy and tumor
cell interaction. The widespread occurrence of HA binding proteins, their
involvement in tissue organization and the control of cellular behavior are
well documented. The low molecular mass HA fragments can also induce a variety
of biological events, including chemokine gene expression, transcription factor
expression and angiogenesis. It is believed that these fragments are more
potent in cellular activities than high molecular mass HA. In this study, we
isolated the various fragments by gel permeation chromatography of
hyaluronidase digested HA and characterized by fluoro assisted carbohydrate electrophoresis
(FACE) and matrix assisted laser desorption ionization analysis (MALDI). Detection
and distribution of cellular receptors in invasive tumor tissues for HA polymer
and HA fragments were determined both by Western
blot and histochemistry. The study demonstrated the overexpression of HA-hexa
binding protein in human tumors of breast and stomach and its involvement
in tumorogenesis.
 
Date 2012-08-07T11:19:15Z
2012-08-07T11:19:15Z
2012-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/14538
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(4) [August 2012]