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<span style="font-size:11.0pt;mso-bidi-font-size: 10.0pt;font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman"; mso-ansi-language:EN-GB;mso-fareast-language:EN-US;mso-bidi-language:AR-SA" lang="EN-GB">Effect of acute exposure of N, N-Dimethylformamide, an industrial solvent on lipid peroxidation and antioxidants in liver and kidney of rats</span>

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Title Effect of acute exposure of N, N-Dimethylformamide, an industrial solvent on lipid peroxidation and antioxidants in liver and kidney of rats
 
Creator Jyothi, Kanagaraj
Kalyani, Durai
Nachiappan, Vasanthi
 
Subject N, N-Dimethylformamide
Hepatotoxicity
Nephrotoxicity
Histopathology
Lipid peroxidation
Oxidative stress
Enzymatic antioxidants
Non-enzymatic antioxidants
 
Description 279-284
N, N-Dimethylformamide (DMF), an industrial
solvent widely used throughout the world is a known toxic compound. Here, we
studied the effects of acute exposure of DMF on liver and kidney in rats. Rats
were treated intraperitoneally with a
single dose of DMF (1.5 g/kg) for 24 and 48 h. Hepatic and nephrotoxicity was
confirmed based on the significant increase in the serum levels of aspartate
amino transferase, alanine amino transferase, alkaline phosphatase, g-glutamyl transferase, urea,
creatinine and electrolytes. Oxidative stress was assessed by determining the
levels of lipid peroxidation (LPO) and antioxidants in liver and kidney.
The LPO levels were elevated in both the tissues upon DMF exposure, whereas the
activities of enzymatic antioxidants SOD, CAT and Gpx and non-enzymatic
antioxidants (glutathione and vitamin C)
were declined. The hepatic- and nephrotoxicity was further confirmed by the increasing
incidence of inflammation in the histopathological studies. The findings
indicate that acute exposure of DMF results in oxidative stress, antioxidant
deficiency, attenuating liver and kidney marker enzymes, resulting in tissue
inflammation and damage.


 
Date 2012-08-07T11:24:03Z
2012-08-07T11:24:03Z
2012-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/14545
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(4) [August 2012]