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Quantitative structure-activity relationship study on N-(pyridin-4-yl)-(indol-3-yl) alkylamides as antiallergic agents

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Title Quantitative structure-activity relationship study on N-(pyridin-4-yl)-(indol-3-yl) alkylamides as antiallergic agents
 
Creator Singh, P
Sharma, B K
Kumar, R
 
Description 351-355
The antihistamine activit y of N-(pyridin
-4-yl)-(indol-3 -y l)

alkylamides has been analyzed using Fujita-Ban and
Hansch

approaches. The analyses have helped to ascertain the
role of different substituents in explaining the antiallergic actions of these  analogues. From both approaches it is revealed
that the small size substituents at R and R2

and non-hydrogen bond acceptor substituent at R
improve histamine antagonist activity of a compound. Likewise, a small incision
such as - CH2CONH-serving as the spacer between pyridinyl and
indolyl rings and a

bigger substituent like 4-FBn at R1 are also desirable for inhibitory activity.

 
 
Date 2012-12-08T16:16:11Z
2012-12-08T16:16:11Z
2002-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15213
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.39(5) [October 2002]