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Hydrocortisone and triiodothyronine regulation of malate-aspartate shuttle enzymes during postnatal development of chicken

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Title Hydrocortisone and triiodothyronine regulation of malate-aspartate shuttle enzymes during postnatal development of chicken
 
Creator Lyngdoh, Herbert G
Sharma, Ramesh
 
Description 170-175
The normal endogenous level of
malale-aspartale shuttle enzymes and its regulation by hydrocortisone and triiodothyronine
were studied in the liver and kidney of 0-, 30- and 60-day old male Rhode
Island Red (RIR) chicken. The endogenous activity of cytosolic malate
dehydrogenase (c-MDH) was significantly higher in the liver or day 30 as
comparcd to day 0 and 60. In contrast, mitochondrial malate dehydrogenase
(m-MDH) activity decreased at day 60 in the liver. However, both c- and m-MDH
had  significantly lower activities at
day 0, which increased sharply at day 30 and 60 in the kidney. On the other
hand. activity of both cytosolic and mitochond ri al aspartate aminolransfera
se (c- and m-AsAT) showed peak value al day 30 in both liver and kidney.
Hydrocortisone administration induced c-MDH in the liver al all the ages studied,
but did not influence the activity of the isoenzymes in the kidney whereas, it
induced m-MDH in the liver at day 0 and in kidney at day 30. Administration of
hydrocortisone. however, did not influence AsAT isoenzymes (c- and m-AsAT)

in either of the tissues at any of the postnatal
ages. Triiodothyronine induced c-MDH in the liver at all the ages whereas kidney
isoenzyme was induced only at day 60. In contrast, m-MDH was induced by triiodothyronine
in both liver and Kidney all day 30 and 60. Administration of triiodothyronine
did not influence c-AsAT of liver and kidney at either of the ages, whereas it
induced m-AsAT of only liver at day 0 and 60. These fin dings indicated a ti
ssue- and age-specific express ion of the malate-spartate shuttle enzymes in
chicken and difference in the regulation exerted by hydrocortisone and triiodothyronine
during postnatal development or chicken.
 
Date 2012-12-24T18:41:50Z
2012-12-24T18:41:50Z
2001-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15290
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(3) [June 2001]