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Influence of 7β-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: <i>In vitro </i>studies </span>

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Title Influence of 7β-hydroxycholesterol on glutathione status and nitric oxide production in macrophages: In vitro studies
 
Creator Bansal, Geetanjali
Singh, Uma
Bansal, M P
 
Description 176-179
Incubation of murine peritoneal macrophages
with 7β hydroxycholesterol (7 β -OH) for 24 hr led to dose-dependent reduction in cellular
glutathione content as well as nitrite levels in the medium. Treatment with an
inorganic form of selenium,

sodium selenite which is a potent
antioxidant, elevated the cellular glutathione levels and decreased nitrite
levels. Our results suggest that 7 β -OH may exert its pro-atherogenic effect by inhibiting
glutathione synthesis and nitric oxide production by

macrophages present in the arterial wall and
thus, impair the cellular antioxidant defense system
 
Date 2012-12-24T18:45:32Z
2012-12-24T18:45:32Z
2001-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15291
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(3) [June 2001]