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Effect of metal ions on binding of bilirubin to erythrocyte membranes

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Title Effect of metal ions on binding of bilirubin to erythrocyte membranes
 
Creator Ali, Mohammad K
Tayyab, Saad
 
Description 230-234
Binding of bilirubin to different erythrocyte
membranes, namely, human, buffalo, sheep and goat, pre-incubated with different
concentrations of metal ions was studied. The results showed that among the
different metal ions used, Ca2+ had the highest potential in increasing the amount of
bound bilirubin followed by Sr2+ and Mg2+, whereas Ba2+ had the lowest

potential. Treatment of these membranes with Ca2+ led to
an increase in the amount of bound bilirubin in all membranes. However, human
erythrocyte membranes pretreated with Ca2+, bound the highest amount of bilirubin compared to
other erythrocyte membranes. Increase in bilirubin binding upon Ca2+ -treatment
can be ascribed to shielding effect, redistribution

of phospholipids as well as increase in surface
hydrophobicity induced by Ca2+ .
 
Date 2012-12-25T18:18:59Z
2012-12-25T18:18:59Z
2001-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15298
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(4) [August 2001]