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Heterogeneity of transport systems for L-glutamine in mouse mammary gland

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Title Heterogeneity of transport systems for L-glutamine in mouse mammary gland
 
Creator Sharma, Rekha
Kansal, Vinod K
 
Description 241-248
The characteristics of the transport systems of
L-glutamine in lactating mouse mammary gland have been studied. L-glutamine uptake
was mediated by three Na+-dependent and one Na+- independent
systems. The 2-(methylamino)isobutyric acid-sensitive component of Na+ -
dependent uptake exhibited the usual characteristics of system A. The other two
Na+ dependent systems, which we have named BCI-dependent and
BCI-independent, are the new systems identified. These are broad specificity
systems and were discriminated on the basis of inhibition analysis. CI
dependency and the effect of preloading mammary tissue with amino acids. While
L-aspargine inhibited the uptake of L-glutamine via both these broad

specificity systems. L-homoserine inhibited the uptake
of L-glutamine via only BCI-dependent system. The uptake of L-glutamine via the
BCI - independent system was upregulated by preloading mammary tissue with
L-serine, while BCI-dependent system was unaffected. The Na+ - independent
uptake of L-glutamine was inhibited by 2-aminobicyclo-

(2.2.1 )heptane carboxylic acid and other neutral
amino acids, and identified as the system L.
 
Date 2012-12-25T18:20:56Z
2012-12-25T18:20:56Z
2001-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15300
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(4) [August 2001]