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Age related effects of organochlorine insecticide lindane on intestinal brush border membrane in rats

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Title Age related effects of organochlorine insecticide lindane on intestinal brush border membrane in rats
 
Creator Labana, S
Bansal, R C
Mahmood, Akhtar
 
Description 249-252
The effect of oral administration of lindane (γ-HCH)
has been studied on the intestine in 10-day, 20-day and 100-day old rats. In 10
day-old suckling pups exposed to lindane, there was a significant decrease in
the activities of sucrase (29%), lactase (20%) and that of alkaline phosphatase
(24%) compared to control. Sialic acid content of the brush borders was

significantly decreased (29%) in 10-day old as well as
in 20- and 100-day old rats (20 and 25% respectively), while fucose content of
the membranes was significantly enhanced in all the age groups upon pesticide
treatment. Among the brush border lipids, cholesterol content was significantly
increased in all the age groups studied, the maximum increase of 35%

being observed in 10-day-old rats. Membrane
phospholipids were also increased in 20- and 100-day old animals (22% each) on
lindane exposure. The present studies indicated that brush border membranes of
suckling rat intestine were more susceptible to pesticide induced changes
compared to older animals.
 
Date 2012-12-25T18:22:23Z
2012-12-25T18:22:23Z
2001-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15301
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(4) [August 2001]