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Effect of aflatoxin B1 on phosphoinositide signal transduction pathway during regeneration of liver cells following partial hepatectomy

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Title Effect of aflatoxin B1 on phosphoinositide signal transduction pathway during regeneration of liver cells following partial hepatectomy
 
Creator Mistry, K J
Krishna, M
Bhattacharya, R K
 
Description 270-273
Aflatoxin B1 (AFB1)
when administered to partially hepatectomised rats 4 hr prior to sacrifice,
activated signalling pathway in regenerating rat liver. The activity of
phosphatidylinositol (PI) kinase was found decreased at 30 min but increased at
24 hr and returned to normal at 48 hr. At 30 min. inositol-IA,5-triphosphate
(IP3) level increased significantly whereas diacylglycerol (DAG)
level dropped. However, at 24 hr and 48 hr, DAG and IP3 showed the
same trend i.e. an increase in their levels. Phosphatidylinositol-4-phosphate
levels were found to increase at 24 hr. Protein kinase C (PKC), activity from
the particulate fraction was significantly inhibited at 30 min, followed by
increase in activity at 24 hr and return to normal at 48 hr. Cytosolic PKC
showed a decrease at 24 hr and a significant increase at 48 hr. At the peak of DNA synthesis (24 hr) following partial
hepatectomy, all these signalling steps had earlier been found to be inhibited,
but the present study shows that aflatoxin B1 administration 4 hr
prior to sacrifice reverses the action. Activation of PKC by aflatoxin B1
during regeneration of liver cells when PKC in normally inhibited, may possibly
create conditions conducive to carcinogenesis.
 
Date 2012-12-25T18:25:52Z
2012-12-25T18:25:52Z
2001-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15305
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(4) [August 2001]