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Age-dependent variations in mitochondrial and cytosolic antioxidant enzymes and lipid peroxidation in different regions of central nervous system of guinea pigs

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Title Age-dependent variations in mitochondrial and cytosolic antioxidant enzymes and lipid peroxidation in different regions of central nervous system of guinea pigs
 
Creator Vohra, BPS
Sharma, S P
Kansal, V K
 
Description 321-326
The age-related changes in the activities of antioxidant enzymes of
mitochondrial and cytosolic fractions were measured in different regions of the
central nervous system (CNS) in 10 and 32 months old guinea pigs. In old
animals, the activities of superoxide dismutase (SOD) and glutathione
peroxidase (GPx) were reduced (p< 0.05) in all the regions of CNS studied
but catalase (CAT) declined significantly only in the cerebral cortex,
hypothalamus and cerebellum. Glutathione reductase (GRd) activity declined in
cerebral cortex and hypothalamus in the cytosolic fractions and only in
cerebellum in the mitochondrial fraction. It is concluded that age-related
decline in the activities of antioxidant enzymes is both region and enzyme
specific. The endogenous lipid peroxide was found to be significantly higher (p
< 0.05) in the 32 month old animals whereas, lipid peroxidation after
incubating the tissue homogenate in air was found to be lower (p
 
Date 2012-12-25T18:35:27Z
2012-12-25T18:35:27Z
2001-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15310
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(5) [October 2001]