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Non-coordinate expression of closely linked mouse casein genes

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Title Non-coordinate expression of closely linked mouse casein genes
 
Creator George, Sisilamma
Springbett, Anthea
Clark, A John
Archibald, Alan L
 
Description 393-398
Expression levels of five mouse casein genes were analysed
in the mammary gland of virgin, pregnant and lactating mice. We have already
shown that the five murine casein genes are arranged in the order, α-β-γ-ε-κ
in a tandem array, very close to each
other in a 250 kb DNA fragment of mouse genome. Northern blot analysis showed
that, of the calcium sensitive casein genes, the ε casein
gene is expressed only during lactation unlike the α-β and γ casein genes which
are expressed during pregnancy and lactation. Even though the α-β and γ genes
exhibited a co-ordinated expression pattern from

mid to the later stages of pregnancy, the mRNA levels
varied considerably (60, 90 and 100% respectively) by the onset of lactation.
The mRNA level of the calcium- insensitive κ casein gene increased
from mid-pregnancy but at a lower rate and reached ~60% by the first day of lactation.
Considering the locations and closeness of the case in genes, a non-coordinate
expression profile is exhibited by the mouse casein genes, particularly the ε casein
gene.

 
 
Date 2012-12-25T19:00:34Z
2012-12-25T19:00:34Z
2001-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15325
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(6) [December 2001]