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Phosphate radical induced oxidation of pyrimidine bases in aqueous solution

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Title Phosphate radical induced oxidation of pyrimidine bases in aqueous solution
 
Creator Kumar, Maram Ravi
Rao, Mundra Thirupathi
Adinarayana, Mundra
 
Description 13-17
The photooxidation of pyrimidine bases viz .uracil and cytosine in presence
of peroxydiphosphate (PDP) in
aqueous solution at natural pH (~7.5) has been carried out in a quantum yield reactor using
a high-pressure mercury lamp. The rates of oxidation and quantum yields of
pyrimidine oxidation have been found to increase with increase in [PDP] while
they are

independent of  [pyrimidine] and light intensity. On the basis of these
experimental results, product analysis and existence of isosbestic points a
probable mechanism is suggested in which peroxydiphosphate ion on photolysis
gives phosphate radical anions which initiates the reaction by adding to C(5)
or C(6) of pyrimidine base leading to the formation of pyrimidine radical via
radical cation or hydrolysis. This further reacts with PDP and gives the final
products 5,6-dihydroxy pyrimidine and isobarbituric acid.
 
Date 2012-12-28T11:34:57Z
2012-12-28T11:34:57Z
2000-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15376
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.37(1) [February 2000]