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A new membrane probing steroidal spin label: Synthesis and applications

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Title A new membrane probing steroidal spin label: Synthesis and applications
 
Creator Katoch, Rita
Trivedi, Girish K
Phadke, Ratna S
 
Description 45-50
The
applicability of a new steroidal spin
label, 3-oxo-androstan-17β-yl-(2",2",6",6"-tetramethyl-N-oxyl)
piperidyl butan- 1', 4'-dioate, in
studying the phase transition properties of model membrane L-α-dipalmitoyl  phosphatidyl choline (DPPC) in the presence
and absence of drugs has been explored. Its synthesis and characterization has  been described, herein. Besides, the
localization of this spin label in lipid liposomes has been studied using
electron spin resonance (ESR), differential scanning calorimetry (DSC) and 1H
and 31P NMR spectroscopic techniques. The label has also been used
to study the permeability of epinephrine into membrane. The results show that the spin label has a
good potential as a spin

probe in the study of biomembranes.
 
Date 2012-12-28T11:31:38Z
2012-12-28T11:31:38Z
2000-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15370
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.37(1) [February 2000]