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Induction of apoptosis in AK-5 cells by rotenone involves participation of Caspases

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Title Induction of apoptosis in AK-5 cells by rotenone involves participation of Caspases
 
Creator Khar, Ashok
Ali, A Mubarak
Begum, Zareena
Pardhasaradhi, B V V
Varalakshmi, Ch
 
Description 77-81
AK-5 tumour cells undergo apoptosis after treatment with rotenone an
electron transport inhibitor and oligomycin which inhibits mitochondrial ATPases.
Apoptotic process involves the induction of caspases 2 and 3, whereas caspase 1
does not seem to be participating in rotenone/oligomycin induced apoptosis.DEVD
which is a specific inhibitor of caspase 3, inhibited apoptosis in AK-5 cells.
We have also observed a significant lowering of intracellular pH in AK-5 cells which are
induced into the apoptotic process by rotenone. These results suggest an
important role for mitochondrial electron transport in the induction of apoptosis
in AK-5 tumour cells.
 
Date 2012-12-31T19:09:46Z
2012-12-31T19:09:46Z
1999-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15431
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(2) [April 1999]