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Modulation of mRNA levels of liver arginase by insulin and vanadate in experimental diabetes

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Title Modulation of mRNA levels of liver arginase by insulin and vanadate in experimental diabetes
 
Creator Salimuddin
Upadhyaya, Kailash C
Raju, Jayadev
Baquer, Najma Z
 
Description 125-128
This work was carried
out to study the modulation of arginase expression in experimental diabetes.
Here, we have demonstrated that liver arginase activity and mRNA levels
increased significantly in diabetic condition. Insulin treatment reverses the
increased activity and mRNA levels nearly to the control values. The reversal
effects of vanadate are found to be similar to that of insulin and this
observation further reiterates the insulin-like effects of vanadate. ELISA and
slot blot assay observations are consistent with biochemical measurements of
enzyme activity. These results show an increase in arginase activity and mRNA
levels in diabetes and decrease in treated animals may be due to the transcriptional
regulation of arginase gene.
 
Date 2012-12-31T19:04:26Z
2012-12-31T19:04:26Z
1999-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15424
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(2) [April 1999]