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Biochemical and dynamic studies of collagen from human normal skin and keloid tissue

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Title Biochemical and dynamic studies of collagen from human normal skin and keloid tissue
 
Creator Prathiba, V
Suryanarayanan, M
 
Description 158-164
Keloids are exuberant
scars, in which collagen, fibronectin and glycosaminoglycans are overdeposited.
Biochemical analysis of the collagen isolated from normal skin and keloid
tissue by pepsin treatment, indicated an increase in the type III and GAG content.
Viscosity measurements of collagen from normal skin and keloid tissue were used
in the' present study to establish the interaction between collagen and GAG.
Physico-chemical properties such as intrinsic viscosity, reduced viscosity and
hydrated volume were computed from viscosity measurements. These measurements
were also used to determine the denaturation temperature of collagen which was
further confirmed by DSC measurements. Chondroitinase has been used in this
study to probe the influence of GAG on the physico-chemical characteristic of
keloid collagen.
 
Date 2012-12-31T19:23:50Z
2012-12-31T19:23:50Z
1999-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15442
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(3) [June 1999]