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Effect of sulphur crosslinking on the stability and transition of triple helical DNA

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Title Effect of sulphur crosslinking on the stability and transition of triple helical DNA
 
Creator Srivastava, Seema
Gupta, Vishwambhar Dayal
Singh, Shyam
 
Description 177-187
In continuation to our work on order-order and
order-disorder transition in triple stranded DNA when it is bounded to netropsin,
we report in this communication the stabilizing / destabilizing effect of
disulphide linkage on the phase dynamics of the triplex using the amended
Zimm-Bragg theory. It is
observed that in contrast to the sequential triplex → duplex
→ single strand melting of the uncrosslinked triplex,
crosslinking causes the triplex state to melt directly to the single stranded
state, with no apparent intermediary of a duplex state. Since there is no
overall difference in the enthalpy of crosslinked and uncrosslinked triplexes,
the transition is entropy driven.
 
Date 2012-12-31T19:22:52Z
2012-12-31T19:22:52Z
1999-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15441
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(3) [June 1999]