ICAR Research Data Repository for Knowledge Management

The leishmanicidal property of piperine
intercalated in liposomes and in man nose-coated liposomes was tested in experimental
visceral leishmaniasis in hamsters. Mannose-coated liposomal piperine
eliminated intracellular amastigotes of Leishmania donovani in splenic
macrophages much more efficiently than did the liposomal piperine or free
piperine. At a dose equivalent to 6 mg/kg body wt every 4^th day for
a total of 4 doses in 12 days, the mannose-coated liposomal piperine was found
to reduce spleen parasite load to the extent of 90% in comparison to that
achieved by liposomal piperine (77%) or free piperine (29%). Histological
examination of spleen and liver function tests showed that the toxicity of
piperine was

reduced when mannosylated liposomal piperine was
administered.