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IgG binding and expression of its receptor in rat intestine during postnatal development

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Title IgG binding and expression of its receptor in rat intestine during postnatal development
 
Creator Gill, Ravinder Kaur
Mahmood, Safrun
Sodhi, C P
Nagpaul, J P
Mahmood, Akhtar
 
Description 252-257
The hinding of 1251
labelled IgG to the microvillus membranes (MVM) has been studied during
postnatal development of rat intestine. The levels of mRNA encoding IgG
receptor were also analyzed by liquid hybridization under these conditions. The
IgG hinding to MVM reached maximum levels by day 12 and showed a gradual decline upon weaning. The FcRn mRNA
was markedly low in adult rats and was maximum during second week or postnatal
development. Administration of cortisone or thyroxine to suckling rats, induced
precocious decline of both IgG binding and the receptor expression. However, insulin
administration did not affect the receptor expression. Scatchard an analysis of
IgG binding to MVM in cortisone injected pups revealed that the observed
inhibit ion in IgG binding was a consequence of a decrease, both in the affinity
constant, (- Ka) as well as in the
number of receptor sites (n) while thyroxine administration caused a reduction
in the number of receptor sites from 2.29 in control to 1.14 nmoles/mg protein in
thyroxine injected pups. These observations indicate that expression of IgG
receptor during postnatal development is a hormone regulated process.
 
Date 2012-12-31T19:46:58Z
2012-12-31T19:46:58Z
1999-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15452
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(4) [August 1999]