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Enterocyte mitochondrial dysfunction due to oxidative stress

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Title Enterocyte mitochondrial dysfunction due to oxidative stress
 
Creator Anup, R
Madesh, M
Balasubramanian, K A
 
Description 266-271
The endogenous production of H2O2
in isolated rat intestinal mitochondria and oxidant induced damage to mitochondria
were examined.  There was an appreciable amount of H2O2
production in presence of succinate, glutamate and pyruvate, while the presence
of rotenone with succinate further increased production. Superoxide generated
by the X-XO system induced membrane permanently transition (MPT), calcium influx,
lipid  peroxidation and changes in
membrane fluidity in mitochondria. A decreased mitochondrial ATPase activity
and uncoupling of respiration was also observed. Spermine inhibited swelling induced
 by X-XO and also blocked the calcium
influx and reversed the membrane fluidity changes.
 
Date 2012-12-31T19:25:35Z
2012-12-31T19:25:35Z
1999-08
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15444
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(4) [August 1999]