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Effect of environmental stress on radiation response of <i>Saccharomyces cerevisiae</i>

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Title Effect of environmental stress on radiation response of Saccharomyces cerevisiae
 
Creator Singh, Rakesh Kumar
Verma, Naresh C
 
Description 296-298
We have investigated the effect of pH shock and oxidative stress (H2O2 effect) both separately and together on the response
of Saccharomyces cerevisiae exposed to UV and gamma radiations for one
hour. Exposure to these environmental stresses resulted in S. cerevisiae cells acquiring resistance
to UV radiation. Presence of cycloheximide (a known protein

synthesis inhibitor) during stress inhibited the acquired
UV resistance. The increased UV resistance is apparently mediated through
nucleotide excision repair as the stress exposures to rad3 mutants (defective
in nucleotide excision repair) do not have any effect on UV response. Both
types of stresses used probably follow the same path of induction of
radioresistance

as the effect of both of them is nonadditive. In the
strains used in our study stress exposure does not have any significant effect
on gamma radiation response.

 
 
Date 2012-12-31T19:56:29Z
2012-12-31T19:56:29Z
1999-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15462
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(5) [October 1999]