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<span style="font-size:14.0pt;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-US;mso-fareast-language: EN-US;mso-bidi-language:AR-SA">Inhibition of a protein tyrosine kinase activity in <i>Plasmodium falciparum </i>by chloroquine</span>

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Title Inhibition of a protein tyrosine kinase activity in Plasmodium falciparum by chloroquine
 
Creator Sharma, Arun
Mishra, Neerad C
 
Description 299-304
The aim of the present study was to establish the
importance of  phosphorylation events for
parasite growth and maturation . Investigations into the cytosolic Plasmodium
falciparum protein tyrosine kinase (PTK) activity revealed that there is a
stage specific increase in the activity, in the order ring < trophozoite
g/ml ) in CQ-S strains. The effect of varying concentration
of CQ on the kinetics of peptide phosphorylation reveal that CQ was a competitive
inhibitor of PTK with respect to peptide substrate and non-competitive with
respect to ATP indicating that CQ inhibits PTK activity by binding with protein
substrate binding site. These data thus suggests that maturation of malaria
parasite may be due to this cellular PTK and its inhibition by CQ could provide
a hypothesis to explain its antimalarial activity and efficacy.
 
Date 2012-12-31T19:48:37Z
2012-12-31T19:48:37Z
1999-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15454
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(5) [October 1999]