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The role of LFA-1 , Mac-1 , ICAM-1 and Ia in the induction of Th-2 type of immune response in spleen during murine syngeneic pregnancy

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Title The role of LFA-1 , Mac-1 , ICAM-1 and Ia in the induction of Th-2 type of immune response in spleen during murine syngeneic pregnancy
 
Creator Hegde, Umashashi C
Nainan, Rachel
 
Description 405-414
Murine syngeneic pregnancy is characterized by the
transient splenomegaly at mid gestation. Recent studies from our laboratory
have indicated the initiation of T-cell dependent B-cell response in the spleen
during early pregnancy (Hegde and Nainan 1998). Present studies
were carried out to understand the role of cell adhesion and MHC class II (Ia)
molecules in the induction of Th-2 type of response in the spleen of pregnant mouse.
Immunochemical localization of ICAM- 1, LFA- 1, Mac- 1 and Ia in spleen have
been carried out at different stages of pregnancy and formation of cell
clusters and natural cell adhesion assay with splenocytes were carried out on
day 1 (D1) pregnancy and compared with control. Upregulation of ICAM- 1, LFA- 1,
Mac- 1 and Ia was observed during early pregnancy. This coincided with the
formation of germinal centers (GC) and Th2 type of interleukins in spleen as
reported earlier. Increased express ion of cell adhesion and Ia molecules during
early pregnancy provides additional evidence for the systemic shift to Th2 type
of immune response in syngeneic

murine pregnancy.
 
Date 2012-12-31T20:06:16Z
2012-12-31T20:06:16Z
1999-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15472
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.36(6) [December 1999]