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Homocysteine in occlusive vascular disease: A risk marker or risk factor

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Title Homocysteine in occlusive vascular disease: A risk marker or risk factor
 
Creator Bhargava, Seema
Ali, Arif
Manocha, Anjali
Kankra, Mamta
Das, Sabari
Srivastava, Lalit Mohan
 
Subject Homocysteine
Hill’s criteria
Risk marker
Risk factor
Occlusive vascular disease
 
Description 414-420
whether it is
just an association (risk marker) or actually a causative factor (risk factor).
To elucidate this, a retrospective statistical analysis was done of data
generated in the course of our study on homocysteine and vascular disease.
Homocysteine, lipid profile components and lipoprotein(a) were estimated in
fasting blood samples drawn from 252 controls and 536 patients of occlusive
vascular disease. The data were analyzed by SPSS version 17. Mean homocysteine
levels were significantly higher (p@20%, when the cut-off was reduced by 5
µmol/L. Statistical analysis of our data revealed that homocysteine conformed
to Hill’s criteria of causation. Moreover, hyperhomocysteinemia was treatable
by the administration of B-vitamins, even if the cause was genetic. Hence
morbidity due to vascular disease could be reduced by identification and
treatment of hyperhomocysteinemia.


 
Date 2012-12-13T07:27:36Z
2012-12-13T07:27:36Z
2012-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/15244
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.49(6) [December 2012]