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Resveratrol diminishes platelet aggregation and increases susceptibility of K562 tumor cells to natural killer cells

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Title Resveratrol diminishes platelet aggregation and increases susceptibility of K562 tumor cells to natural killer cells
 
Creator Toliopoulos, Ioannis K
Simos, Yannis V
Oikonomidis, Stergios
Karkabounas, Spyros C
 
Subject Natural killer cells
Resveratrol
Platelets
Aggregation
 
Description 14-18
Platelet aggregation around migrating cancer
cells protects them against the activity of natural killer cells (NKCs). The
inability of immune system to response results in the progression of malignant
diseases. This study was designed to evaluate the effects of resveratrol (3,
4', 5-trihydroxystilbene) on platelet aggregation and NKCs activity.
Experiments were designed to evaluate the platelet aggregation, production of
thromboxane B2 (TXB2), estimation of
expression of the platelet receptor GpIIb/IIIa (major biological markers for
platelet aggregation) and functional activity of the NKCs against the K562
cancer cell line after incubation with various concentrations of reveratrol.
Resveratrol at a concentration of 3 × 10-3Μ completely inhibited
platelet aggregation (p
 
Date 2013-02-23T11:19:45Z
2013-02-23T11:19:45Z
2013-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/16060
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(1) [February 2013]