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Gender differences in alcohol-induced oxidative stress and altered membrane properties in erythrocytes of rats

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Title Gender differences in alcohol-induced oxidative stress and altered membrane properties in erythrocytes of rats
 
Creator Reddy, Kindinti Rameshwar
Reddy, Vaddi Damodara
Padmavathi, Pannuru
Kavitha, Godugu
Saradamma, Bulle
Varadacharyulu, N C
 
Subject Alcohol
Erythrocyte membrane
Fluidity
Gender
Nitric oxide
 
Description 32-39
Alcohol-induced
oxidative stress leads to imbalance between reactive oxygen species (ROS) and
the antioxidant
defense system, resulting in oxidative damage to membrane components such as
lipids and proteins, ultimately altering membrane properties. In this study, we
assessed oxidative stress status and alterations in erythrocyte membrane
properties in alcohol-administered rats with respect to gender difference.
Alcohol (20% v/v) administered rats of both genders showed significant changes
in plasma lipid profile with elevated nitrite/nitrate levels. Furthermore,
alcohol-administration significantly decreased erythrocyte antioxidant enzymes
and enhanced erythrocyte membrane lipid peroxidation, cholesterol/phospholipid
(C/P) ratio and Na+/K+-ATPase activity in both males and
females. Besides, anisotropic studies revealed that alcohol-administration
significantly decreased erythrocyte membrane fluidity. In conclusion, alcohol-
administration significantly increased oxidative stress by decreasing
antioxidant status, and subsequent generation of ROS altered membrane
properties by altering fluidity and Na+/K+-ATPase
activity. Female rats were more vulnerable to
alcohol-induced biochemical and biophysical changes in plasma and erythrocyte
including oxidative stress than male rats.
 
Date 2013-02-23T11:19:09Z
2013-02-23T11:19:09Z
2013-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/16059
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(1) [February 2013]