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Combined effects of age and diet-induced obesity on biochemical parameters and cardiac energy metabolism in rats

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Title Combined effects of age and diet-induced obesity on biochemical parameters and cardiac energy metabolism in rats
 
Creator Chuffa, Luiz Gustavo de Almeida
Seiva, Fábio Rodrigues Ferreira
 
Subject Obesity
Ageing
Dyslipidemia
Cardiac metabolism
Oxidative stress
 
Description 40-47
Obesity is often associated with
decreased fat oxidation and aging is a well-recognized risk factor for
cardiovascular disease. This study investigated calorimetric and morphometric parameters, as
well as the glucose levels, lipid profile and cardiac energy metabolism in
young and old, controls and obese rats. The animals were divided into four
groups: Group I (GI): young rats fed normal diet
for 75 days; Group II (GII): young rats fed
hypercaloric diet (HD) for 75 days; Group
III (GIII): old rats fed normal diet for 510 days; and Group IV (G IV): old rats fed HD for 510 days. The following
analyses were performed: calorimetric, glucose and lipid concentrations,
atherogenic index (AI), total antioxidant substances (TAS), fat depots, cardiac
lipid hydroperoxide (LH) and cardiac lactate dehydrogenase (LDH), citrate synthase (CS), phosphofructokinase (PFK) and pyruvate dehydrogenase (PDH) activities. Older animals were heavier than young
and the hypercaloric animals were heavier than controls. Animals from GIV had
lower fat oxidation than GIII, which in turn, had higher fat oxidation than
GI. Total cholesterol, LDL-C and all fat depots were higher in the GII, as
compared to GI. The GIV rats had higher VLDL, retroperitoneal fat, serum lipids
and cardiac glycogen levels than GII. Furthermore, GIV rats had higher fat
depots, triacylglycerol, total
cholesterol and VLDL than GIII. Animals from GII
and -IV showed higher LH and AI than age-matched controls. Older hypercaloric
rats also had higher TAS than older control rats, which also had lower LH and
TAS than younger control rats. Aged animals had increased CS and LDH and
decreased PFK and PDH activities. Additionally, GIV rats exhibited an increase
in PDH activity, compared to GIII. We conclude that the consumption of HD
coupled with aging leads to impaired basal and cardiac metabolism.
 
Date 2013-02-23T11:20:50Z
2013-02-23T11:20:50Z
2013-02
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/16061
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(1) [February 2013]