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Association of family history of type 2 diabetes mellitus with markers of endothelial dysfunction in South Indian population

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Title Association of family history of type 2 diabetes mellitus with markers of endothelial dysfunction in South Indian population
 
Creator Dhananjayan, R
Malati, T
Brindha, G
Kutala, Vijay Kumar
 
Subject Diabetes
Familial history
Diabetic peripheral vasculopathy
Endothelial dysfunction
Intimal medial thickening
 
Description 93-98
Studies indicate that risk for type 2 diabetes
mellitus (T2D) or cardiovascular disease is detectable in childhood, though
these disorders may not emerge until adulthood. This study was aimed to assess
the markers of endothelial dysfunction in patients with the family history of
T2D from South Indian population. A total of 450 subjects were included in the
study comprising Group I (n = 200) of T2D, Group II (n = 200) of age- and
sex-matched healthy controls, Group III (n = 25) of children of T2D patients
and Group IV (n = 25) of children of healthy controls. Results showed that
intimal medial thickening (IMT) was significantly higher in T2D patients,
compared with control subjects with no family history of diabetes. The fasting
plasma glucose, glycated hemoglobin, serum total cholesterol, triglyceride, LDL-cholesterol,
apolipoprotein B (ApoB) and high-sensitive C-reactive protein (hsCRP) levels
were significantly increased, whereas
HDL-cholesterol and serum nitrite levels were significantly decreased in T2D
patients. However, children of T2D patients who were not diabetic did not show
significant increase in the IMT, as compared to those of healthy controls. In
conclusion, the present study demonstrated that IMT was significantly higher in
the T2D patients and increased with age and family history. The increased
levels of lipids, hsCRP, IMT and decreased nitrite levels might contribute to
the risk of endothelial dysfunction in patients with T2D. However, further
studies are warranted with other biomarkers of endothelial dysfunction in T2D
patients with increased sample size.
 
Date 2013-04-18T07:37:10Z
2013-04-18T07:37:10Z
2013-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/17106
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(2) [April 2013]