Record Details

L-Arginine attenuates oxidative stress condition during cardiomyopathy

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title L-Arginine attenuates oxidative stress condition during cardiomyopathy
 
Creator Tripathi, Pratima
Pandey, Shivani
 
Subject Cardiomyopathy
Oxidative stress
L-Arginine
Nitric oxide
Pro-oxidant shift
 
Description 99-104
Increased production of oxygen free radicals
and decreased oxidant capacity occur in coronary artery diseases (CAD). This
pro-oxidant shift in intracellular redox state may induce cell death by either
direct cell membrane damage by lipid peroxidation or apoptosis through
activation of transcription factors. These changes occur not only in
cardiomyocytes, but also in cardiac sympathetic nerves, which are very
sensitive to oxidative damage. Patients with heart
failure encounter reduced peripheral blood flow at rest, during
exercise and in response to endothelium-dependent vasodilators.
Current treatments of cardiomyopathy, a degenerative condition of the
myocardium frequently associated with heart failure have done little to enhance
patient survival. Decreased myocardial contractility and altered regulation of
peripheral circulation along with oxidative conditions are important
contributors to the symptoms and prognosis of the disease process. Nitric oxide formed from L-arginine (2-amino-5
guanidinovaleric acid) metabolism in endothelial
cells contributes to regulation of blood flow under these
conditions. L-Arginine is the precursor of nitric oxide, an endogenous
messenger molecule involved in a variety of endothelium-mediated physiological
effects in the vascular system. In the present study, we investigated the
effect of oral administration of L-arginine (3 g/day) on the intracellular
redox status of the patients of ischemic cardiomyopathy aged 45-60 yrs. The
enzymatic and non-enzymatic antioxidant parameters like superoxide dismutase, catalase, total
thiols (TSH) and
ascorbic acid along with pro-oxidant parameters, such
as xanthine oxidase, as
well as index of oxidative stress as protein carbonyl
content and malondialdehyde (a marker of lipid peroxidation) were investigated
in the plasma and RBC lysate. L-Arginine (3 g/day) administration was found to
improve the levels of these parameters in the patients and regulate the blood
flow, as evident by the improved blood pressure of the patients. Thus, it is
inferred that L-arginine attenuates the oxidative stress conditions along with
maintaining the blood pressure rate of patients suffering from cardiomyopathy.
 
Date 2013-04-18T07:35:41Z
2013-04-18T07:35:41Z
2013-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/17102
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(2) [April 2013]