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Effect of phosphorohydrazone derivatives of chromone on fibrin polymerization in the presence of bFGF

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Title Effect of phosphorohydrazone derivatives of chromone on fibrin polymerization in the presence of bFGF
 
Creator Michalska, Marta
Mirowski, Marek
Kaplińska, Katarzyna
Kusztal, Dorota
Łazarenkow, Andrzej
Nawrot-Modranka, Jolanta
 
Subject Phosphorohydrazone
Chromone
bFGF
Polymerization
Fibrin
 
Description 227-232
The effect of ten phosphorohydrazone
derivatives of chromone on the fibrin formation process was evaluated in the
presence of basic fibroblast growth factor (bFGF), which plays an important
role in tumor angiogenesis. The relationship between the chemical properties of
the derivatives and the resulting
fibrin structure was also examined. The structure of fibrin was analyzed by UV
spectrophotometry and the degree of bFGF binding to fibrin was estimated by
Western blotting. The measurements were taken at 3 different pH values: 6.64,
7.60 and 8.40. Three of the analyzed phosphorohydrazone derivatives (compounds 2, 7 and 10)
demonstrated the most significant influence on reduction of polymerization at
the studied pH values.


 
Date 2013-06-04T12:43:30Z
2013-06-04T12:43:30Z
2013-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/18683
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(3) [June 2013]