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Relationship between cyclin D1 (A870G) gene polymorphism and lung cancer

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Title Relationship between cyclin D1 (A870G) gene polymorphism and lung cancer
 
Creator Cakina, Suat
Gulyasar, Tevfik
Ozen, Alaattin
Sipahi, Tammam
Kocak, Zafer
Sener, Seralp
 
Subject Lung cancer
Cyclin D1
Gene polymorphism
 
Description 233-236
The
roles of many genes in the pathophysiology of lung cancer have been
investigated in different studies. Cyclin
D1 (CCND1) gene plays a significant role in the transition from G1 to S phase
of the cell cycle and in the phosphorylation of retinoblastoma tumor suppressor
protein.
In this study, we aimed to identify the relationship
between CCND1 A870G gene polymorphism with lung cancer. CCND1 A870G genotypes
were determined in 75 patients with lung cancer and in 65 control subjects. DNA
was isolated from blood samples and then CCND1 A870G gene polymorphism was
identified using PCR and RFLP assay. The distribution of CCND1 A870G
polymorphism did not show any significant differences in all lung cancer
patients and controls. There was no correlation between CCND1 A870G
polymorphism and histopathological findings. However, the
AA + AG genotype was significantly higher in metastatic patients, when compared
with non-metastatic patients. Thus, the results show that CCND1 gene polymorphism may be a
predictor for detecting patients with poor survival who having
metastatic disease.


 
Date 2013-06-04T13:01:15Z
2013-06-04T13:01:15Z
2013-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/18691
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(3) [June 2013]