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Preputial gland activates olfactory receptor neurons in rat: Calcium imaging study using laser scanning confocal microscopy

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Title Preputial gland activates olfactory receptor neurons in rat: Calcium imaging study using laser scanning confocal microscopy
 
Creator Ponmanickam, Ponnirul
Archunan, Govindaraju
Achiraman, Shanmugam
Sankar, Ramaiyan
Saito, Toshiyuki
Habara, Yoshiaki
 
Subject Olfactory receptor neurons
Main olfactory system
Calcium imaging
Preputial gland
Pheromone
Rat
 
Description 242-246
The rodent preputial gland is one of the
major sources of odours and is reported to be involved in several behavioural
activities. However, how the preputial gland initiates the olfactory response
to manifest the effects is not known. Olfactory
receptor neurons (ORNs) present in the olfactory epithelium are involved in the
perception of odorant/pheromonal compounds. In the
present study, the response of rat ORNs to preputial gland extract was
evaluated by calcium imaging analysis. We found that some rat ORNs responded to
the preputial gland extract by exhibiting an intracellular calcium response. By
contrast, the ORNs did not respond at all to the foot pad extract (control).
The results
indicated that the substances contained in the preputial gland might interact
with a type of receptor expressed in the female rat ORNs, suggested to manifest
the behavioural responses, such as social and sexual interactions. This study
provided the first
evidence of activation of ORNs by the preputial gland extract.
 
Date 2013-06-04T12:46:21Z
2013-06-04T12:46:21Z
2013-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/18685
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.50(3) [June 2013]