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Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma

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Title Enhanced expression of heterotrimeric GTP-binding protein subunits in Zajdela ascitic hepatoma
 
Creator Sharma, S K
Das, M R
 
Description 148-154
G protein beta subunit (Gβ2) is over-expressed
in Zajdela ascitic hepatoma (ZAH), a rat ascitic tumour, at mRNA as well as protein
levels. Nuclear run-off transcription analysis suggests that the expression of
Gβ2 in ZAH is regulated mainly at transcriptional as well as post-transcriptional
levels. Gαi3 is also over-expressed in ZAH. No amplification or any change in
the organization of the genes for Gβ2 or Gαi3 was observed. It is possible that
the over-expression of G protein subunits in ZAH could provide proliferative advantage
to the cells by virtue of their effects on second messenger systems.
 
Date 2013-07-15T08:33:28Z
2013-07-15T08:33:28Z
2002-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19771
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.39(3) [June 2002]