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Expression of sodium-glucose co-transporter and brush border disaccharidases in <i>Giardia lamblia </i>infected rat intestine

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Title Expression of sodium-glucose co-transporter and brush border disaccharidases in Giardia lamblia infected rat intestine
 
Creator Mahmood, S
Sodhi, C P
Ganguly, N K
 
Description 185-190
The absorption of D-glucose and brush
border membrane disaccharidases in the intestine of rat during infection by Giardia
lamblia has been studied. The level of mRNA encoding Na+/glucose
co-transporter (SGLT1) and brush border sucrase and lactase activities were
also analyzed. At the peak of infection, i.e, day 7,11 and 15 post-infection,
there was a marked decrease in the signal of 4.5 kb and 2.8 kb mRNAs encoding
SGTL1 compared to the controls. A similar decrease in sucrase and lactase mRNA's
(6.5 kb and 6.8 kb respectively) was also observed under these conditions. This
corresponds to observed decrease in the rate of Na+-dependent D-glucose uptake and low activities
of brush border sucrase and lactase

under these conditions. There was no
change in Na+-independent D-glucose uptake in giardia infected rat
intestine. These findings suggest that the down regulation of the expression of
SGLT1 and brush border sucrase and lactase activities may be responsible for
the observed malabsorption in G. lamblia infection.
 
Date 2013-07-15T09:18:14Z
2013-07-15T09:18:14Z
2002-06
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19776
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.39(3) [June 2002]