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Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice

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Title Dietary regulation of adenosine deaminase activity in stomach, small intestine and spleen of mice
 
Creator Ray, Indrani
Sharma, Ramesh
 
Description 419-421
Activity of adenosine deaminase (ADA) and its regulation by
dietary restriction were studied in the stomach, small intestine and spleen of mice.
ADA activity (U/mg
protein) was highest in the stomach, followed by small intestine and spleen of mice
on normal diet. The activity decreased significantly in the stomach (41%) and
small intestine (45%) of 24 hr fasted mice, when compared to mice fed ad-libitum.
However, ADA
activity in spleen did not show any change by dietary intervention. Refeeding of
fasted mice for 24 hr restored the activity of ADA in tissues. In addition, dietary restriction
(alternate days of feeding for three months) had a cumulative effect, whereby ADA
activity decreased significantly in the stomach (53% on the day of feeding and 60%
on the day of fasting) and small intestine (50% and 54% on the day of feeding and
fasting, respectively) without any change in activity in spleen. These findings
indicate that dietary restriction reduces ADA
activity in a tissue-specific manner. Long-term dietary restriction leads to a
cumulative adaptation in lowering the ADA
activity of GIT, but not in spleen.
 
Date 2013-07-15T09:50:42Z
2013-07-15T09:50:42Z
2002-12
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19788
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.39(6) [December 2002]