Record Details

Molecular modelling of MHC class I carbohydrates

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Molecular modelling of MHC class I carbohydrates
 
Creator Mandal, Tarun K
Mukhopadhyay, Chaitali
 
Description 96-103
In this article we present the results of
molecular modelling of four complex carbohydrates which have been found in the
MHC class I proteins. Though these proteins show diversity in their sequences,
the glycosylation sites are highly conserved indicating a possible
structural/functional role of the glycan chain. Similar glycan chains have been
found linked

with other proteins of completely
different function, such as IgG, and erythropoeitin. Thus, the molecular
modelling of these carbohydrates will not only provide structural/dynamic
information of these complex molecules but will also provide conformational information
which can be utilised to build the glycoprotein model s. The results presented
here indicate that although several linkages show less conformational
flexibility, terminal linkages can be quite flexible.
 
Date 2013-07-16T06:28:48Z
2013-07-16T06:28:48Z
2001-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19806
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(1-2) [February-April 2001]