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Sequence-based structural signatures of genome evolution

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Title Sequence-based structural signatures of genome evolution
 
Creator Kundu, Sudip
Bandyopadhyay, Debashis
Thakur, Ashoke Ranjan
 
Description 104-106
Among the multitude of methods available
for the study of origin and evolution of various life forms on Earth, the
phylogenetic approach, i.e. the delineation of natural genetic relatedness amongst
different groups of organisms, has been of particular interest to evolutionary
biologists. An approach towards analysing phylogeny is the comparison of genome
sequences of extant organisms by a variety of computational techniques. These
studies rely mostly on the similarity or dissimilarity in global character of
the genome in terms of sequence, without any consideration to its structure. In
this work, we report a potentially new methodology towards elucidation of
molecular phylogeny. The approach considers a structural parameter of the
genome, namely its flexibility, and uses it to compare the small subunit
ribosomal ribonucleic acid (SSUrRNA) gene from a cross-section of species. We
find that the flexibility pattern of the genome is strikingly similar in
organisms that are closer in evolutionary distance than the ones that are
separated. This method of comparison thus might be utilised in constructing
phylogenetic trees from flexibility patterns derived from nucleotide sequence.
 
Date 2013-07-16T06:30:44Z
2013-07-16T06:30:44Z
2001-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19807
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.38(1-2) [February-April 2001]