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Succinate oxidase and fumarate reductase systems of filarial parasite <i>Setaria digitata</i>

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Title Succinate oxidase and fumarate reductase systems of filarial parasite Setaria digitata
 
Creator Unnikrishnan, L S
Raj, R Kaleysa
 
Description 130-134
Activities of succinate oxidase, fumarate
reductase (FR) and succinate dehydrogenase (SOH) under a set of defined conditions
were determined in the mitochondrial isolate from Setaria digitata , the
filarial parasite from the cattle Bos indicus. Presence of only two
activities namely SDH and succinate- UQ reductase of the succinate oxidase
system could be detected in S. digitata. In the absence of
cytochromes, the 3rd enzyme of the complex namely cytochrome oxidase is absent and
it is proposed that an alternative oxidase is responsible for completing the succinate
oxidation expressed as succinate oxidase activity. Though SDH and FR catalyse reverse
reactions, they responded differently to modulators such as oxaloacetate, aspartate,
alanine, pyruvate and fumarate. The degree of response of the two activities against
inhibitors of electron transport was also different. Interestingly fumarate caused
only 50% inhibition of succinate oxidation, while the effect against FR was more
convincing.
 
Date 2013-07-16T07:19:11Z
2013-07-16T07:19:11Z
2000-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19820
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.37(2) [April 2000]