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Regulation of nitric oxide production by cytokines in human macrophages: <span style="font-size:12.0pt;line-height:115%;font-family:"Times New Roman"; mso-fareast-font-family:"Times New Roman";mso-ansi-language:EN-IN;mso-fareast-language: EN-IN;mso-bidi-language:HI">Possible role in <i>P. vivax </i>malaria</span>

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Title Regulation of nitric oxide production by cytokines in human macrophages: Possible role in P. vivax malaria
 
Creator Sharma, Arun
Kabilan, Lalitha
 
Description 313-317
Production of reactive nitrogen
intermediates (RNI) by macrophages in response to the malaria antigen of P. vivax
and various cytokines was evaluated. Live malaria antigens, interferon-γ, concanavalin
A, interleukin-6 and tumour necrosis factor-α induced production of RNI in a dose
dependent manner. RNI production was found to be steadily increased for a period
of 72 hr and it was further enhanced when the live malaria antigen was co-incubated
with interleukin-6 and interferon-γ and/or tumour necrosis factor-α. L-N-monomethyl arginine (L-NMA) and polymyxin B were
found to inhibit the production of RNI. Production of RNI by cAMP however, was
not inhibited by polymyxin B. Dead parasites (heated) did not affect the
production of RNI. Our results are thus consistent with the possibility that cytokines
may contribute to the pathology of the host cells and also to the parasite
immunosuppression through the production of the reactive nitrogen intermediates.
 
Date 2013-07-16T09:06:06Z
2013-07-16T09:06:06Z
2000-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19838
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.37(5) [October 2000]