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Synthesis, conformation and vibrational dynamics of apolipoprotein B fragment, -Asn-Cys-Lys-Val-Glu-Leu-

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Title Synthesis, conformation and vibrational dynamics of apolipoprotein B fragment, -Asn-Cys-Lys-Val-Glu-Leu-
 
Creator Srivastava, Seema
Melkani, Girish Chandra
Singh, Shyam
Gupta, Vishwambhar Dayal
 
Description 318-333
It is assumed that all biological processes
are dynamical in nature and the low frequency collective modes, particularly the
skeletal modes arising from the main chain and the side chain play an important
role in such processes. To identify these a complete normal mode analysis of the
hexapeptide -Asn-Cys-Lys-Yal-Glu-Leu-, a
fragment of apolipoprotein B has been carried out. The assignment of modes is greatly
assisted by similar studies on the tetra -Cys-Lys-Val-Glu- and tripeptides (-Asn-Cys-Lys-, -Yal-Glu-Leu-) fragments of the hexapeptide. All the
four peptides have been synthesized by the solid phase peptide method using 9-flurrenyl
methyloxycarbonyl (Fmoc) on 4-methyl benzhyldrylamine (MBHA) and Wang's resins.
Their conformation is determined from the Ramachandran Maps which are based on the
global energy minimization method. It is supported by the propensity parameters
for the amino acids.
 
Date 2013-07-16T09:08:02Z
2013-07-16T09:08:02Z
2000-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://hdl.handle.net/123456789/19839
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.37(5) [October 2000]